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correlograms displaying pearson's correlation coefficient gene expression in hpciss  (RStudio)

 
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    RStudio correlograms displaying pearson's correlation coefficient gene expression in hpciss
    ABCB1 , CYP3A4 , PXR , and RXRA gene expression in hPCIS determined by qRT-PCR. Fold changes in ABCB1 and CYP3A4 mRNA levels in hPCISs incubated with RIF (30 µM) for 4, 8, 12, 16, 20, 24, and 48 h (A) , relative to expression in RIF-free controls, showing that RIF significantly increased mRNA levels of both genes in samples from all donors at all tested time points (one-sample t -tests, three slices from one donor: *, p < 0.05; **, p < 0.01; ***, p < 0.001). PXR (B) and RXRA (C) were demonstrated to be expressed in hPCISs incubated with RIF (30 µM) at all tested time points. Amounts of PXR and RXRA transcripts are presented in arbitrary units (a.u.), calculated as 2 −∆Ct × 10 6 . (D) The matrix of <t>Pearson’s</t> coefficients of correlation was used to assess associations among all targeted transcripts in RIF-treated hPCISs (positive in blue and negative in red, with color intensity proportional to the magnitude of the coefficients). Asterisks indicate significant differences: *, p < 0.05; **, p < 0.01; ***, p < 0.001.
    Correlograms Displaying Pearson's Correlation Coefficient Gene Expression In Hpciss, supplied by RStudio, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/correlograms+displaying+pearson's+correlation+coefficient+gene+expression+in+hpciss/correlograms+displaying+pearson+s+correlation+coefficient+gene+expression+in+hpciss/pmc08220149-94-0-22
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    correlograms displaying pearson's correlation coefficient gene expression in hpciss - by Bioz Stars, 2026-09
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    1) Product Images from "Rifampicin Induces Gene, Protein, and Activity of P-Glycoprotein (ABCB1) in Human Precision-Cut Intestinal Slices"

    Article Title: Rifampicin Induces Gene, Protein, and Activity of P-Glycoprotein (ABCB1) in Human Precision-Cut Intestinal Slices

    Journal: Frontiers in Pharmacology

    doi: 10.3389/fphar.2021.684156

    ABCB1 , CYP3A4 , PXR , and RXRA gene expression in hPCIS determined by qRT-PCR. Fold changes in ABCB1 and CYP3A4 mRNA levels in hPCISs incubated with RIF (30 µM) for 4, 8, 12, 16, 20, 24, and 48 h (A) , relative to expression in RIF-free controls, showing that RIF significantly increased mRNA levels of both genes in samples from all donors at all tested time points (one-sample t -tests, three slices from one donor: *, p < 0.05; **, p < 0.01; ***, p < 0.001). PXR (B) and RXRA (C) were demonstrated to be expressed in hPCISs incubated with RIF (30 µM) at all tested time points. Amounts of PXR and RXRA transcripts are presented in arbitrary units (a.u.), calculated as 2 −∆Ct × 10 6 . (D) The matrix of Pearson’s coefficients of correlation was used to assess associations among all targeted transcripts in RIF-treated hPCISs (positive in blue and negative in red, with color intensity proportional to the magnitude of the coefficients). Asterisks indicate significant differences: *, p < 0.05; **, p < 0.01; ***, p < 0.001.
    Figure Legend Snippet: ABCB1 , CYP3A4 , PXR , and RXRA gene expression in hPCIS determined by qRT-PCR. Fold changes in ABCB1 and CYP3A4 mRNA levels in hPCISs incubated with RIF (30 µM) for 4, 8, 12, 16, 20, 24, and 48 h (A) , relative to expression in RIF-free controls, showing that RIF significantly increased mRNA levels of both genes in samples from all donors at all tested time points (one-sample t -tests, three slices from one donor: *, p < 0.05; **, p < 0.01; ***, p < 0.001). PXR (B) and RXRA (C) were demonstrated to be expressed in hPCISs incubated with RIF (30 µM) at all tested time points. Amounts of PXR and RXRA transcripts are presented in arbitrary units (a.u.), calculated as 2 −∆Ct × 10 6 . (D) The matrix of Pearson’s coefficients of correlation was used to assess associations among all targeted transcripts in RIF-treated hPCISs (positive in blue and negative in red, with color intensity proportional to the magnitude of the coefficients). Asterisks indicate significant differences: *, p < 0.05; **, p < 0.01; ***, p < 0.001.

    Techniques Used: Gene Expression, Quantitative RT-PCR, Incubation, Expressing

    Related Articles

    Gene Expression:

    Article Title: Rifampicin Induces Gene, Protein, and Activity of P-Glycoprotein (ABCB1) in Human Precision-Cut Intestinal Slices
    Article Snippet: All data were processed using GraphPad Prism 8.31 (GraphPad Software, Inc., San Diego, CA, United States). .. Correlograms displaying Pearson’s correlation coefficient gene expression in hPCISs (considers all times points, in which gene expressions were analyzed) were generated using R-Studio 1.3.959. ..

    Generated:

    Article Title: Rifampicin Induces Gene, Protein, and Activity of P-Glycoprotein (ABCB1) in Human Precision-Cut Intestinal Slices
    Article Snippet: All data were processed using GraphPad Prism 8.31 (GraphPad Software, Inc., San Diego, CA, United States). .. Correlograms displaying Pearson’s correlation coefficient gene expression in hPCISs (considers all times points, in which gene expressions were analyzed) were generated using R-Studio 1.3.959. ..



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    RStudio correlograms displaying pearson's correlation coefficient gene expression in hpciss
    ABCB1 , CYP3A4 , PXR , and RXRA gene expression in hPCIS determined by qRT-PCR. Fold changes in ABCB1 and CYP3A4 mRNA levels in hPCISs incubated with RIF (30 µM) for 4, 8, 12, 16, 20, 24, and 48 h (A) , relative to expression in RIF-free controls, showing that RIF significantly increased mRNA levels of both genes in samples from all donors at all tested time points (one-sample t -tests, three slices from one donor: *, p < 0.05; **, p < 0.01; ***, p < 0.001). PXR (B) and RXRA (C) were demonstrated to be expressed in hPCISs incubated with RIF (30 µM) at all tested time points. Amounts of PXR and RXRA transcripts are presented in arbitrary units (a.u.), calculated as 2 −∆Ct × 10 6 . (D) The matrix of <t>Pearson’s</t> coefficients of correlation was used to assess associations among all targeted transcripts in RIF-treated hPCISs (positive in blue and negative in red, with color intensity proportional to the magnitude of the coefficients). Asterisks indicate significant differences: *, p < 0.05; **, p < 0.01; ***, p < 0.001.
    Correlograms Displaying Pearson's Correlation Coefficient Gene Expression In Hpciss, supplied by RStudio, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/correlograms+displaying+pearson's+correlation+coefficient+gene+expression+in+hpciss/correlograms+displaying+pearson+s+correlation+coefficient+gene+expression+in+hpciss/pmc08220149-94-0-22
    Average 90 stars, based on 1 article reviews
    correlograms displaying pearson's correlation coefficient gene expression in hpciss - by Bioz Stars, 2026-09
    90/100 stars
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    ABCB1 , CYP3A4 , PXR , and RXRA gene expression in hPCIS determined by qRT-PCR. Fold changes in ABCB1 and CYP3A4 mRNA levels in hPCISs incubated with RIF (30 µM) for 4, 8, 12, 16, 20, 24, and 48 h (A) , relative to expression in RIF-free controls, showing that RIF significantly increased mRNA levels of both genes in samples from all donors at all tested time points (one-sample t -tests, three slices from one donor: *, p < 0.05; **, p < 0.01; ***, p < 0.001). PXR (B) and RXRA (C) were demonstrated to be expressed in hPCISs incubated with RIF (30 µM) at all tested time points. Amounts of PXR and RXRA transcripts are presented in arbitrary units (a.u.), calculated as 2 −∆Ct × 10 6 . (D) The matrix of Pearson’s coefficients of correlation was used to assess associations among all targeted transcripts in RIF-treated hPCISs (positive in blue and negative in red, with color intensity proportional to the magnitude of the coefficients). Asterisks indicate significant differences: *, p < 0.05; **, p < 0.01; ***, p < 0.001.

    Journal: Frontiers in Pharmacology

    Article Title: Rifampicin Induces Gene, Protein, and Activity of P-Glycoprotein (ABCB1) in Human Precision-Cut Intestinal Slices

    doi: 10.3389/fphar.2021.684156

    Figure Lengend Snippet: ABCB1 , CYP3A4 , PXR , and RXRA gene expression in hPCIS determined by qRT-PCR. Fold changes in ABCB1 and CYP3A4 mRNA levels in hPCISs incubated with RIF (30 µM) for 4, 8, 12, 16, 20, 24, and 48 h (A) , relative to expression in RIF-free controls, showing that RIF significantly increased mRNA levels of both genes in samples from all donors at all tested time points (one-sample t -tests, three slices from one donor: *, p < 0.05; **, p < 0.01; ***, p < 0.001). PXR (B) and RXRA (C) were demonstrated to be expressed in hPCISs incubated with RIF (30 µM) at all tested time points. Amounts of PXR and RXRA transcripts are presented in arbitrary units (a.u.), calculated as 2 −∆Ct × 10 6 . (D) The matrix of Pearson’s coefficients of correlation was used to assess associations among all targeted transcripts in RIF-treated hPCISs (positive in blue and negative in red, with color intensity proportional to the magnitude of the coefficients). Asterisks indicate significant differences: *, p < 0.05; **, p < 0.01; ***, p < 0.001.

    Article Snippet: Correlograms displaying Pearson’s correlation coefficient gene expression in hPCISs (considers all times points, in which gene expressions were analyzed) were generated using R-Studio 1.3.959.

    Techniques: Gene Expression, Quantitative RT-PCR, Incubation, Expressing